Comparison of Midazolam with Propofol and Propofol Alone in Minor Oral and Maxillofacial Surgical Procedures

Background and Objectives: The present study was conducted to assess the effects of low dose Midazolam with Propofol and Propofol alone during minor oral and maxillofacial surgeries; to evaluate the level of sedation, post-operative amnesia, and condition of the patient during surgery, patient satisfaction and opinion. Material and Methods: Fifty ASA Grade I and II patients were randomly allocated into two equal groups (n = 25 in each). The Propofol group, received Propofol bolus of 0.7mg/kg and the Midazolam + Propofol group received a low dose Midazolam bolus of 0.03mg/kg prior to Propofol bolus of 0.7mg/kg. Propofol continuous infusion of 50 microgram/kg/min was given after the bolus in both the groups. Results: The level of sedation was better in the Midazolam + Propofol during the operative procedure. Patient condition was rated excellent during the operative procedure in 72% patients in the Midazolam + Propofol group and 60% patients in the Propofol group by the surgeon. The level of amnesia was greater in Midazolam + Propofol group and statistically significant. 80% patients in the Midazolam + Propofol group and 48 % in the propofol alone group were well satisfied with the sedation techniques. Conclusion: The addition of low dose Midazolam to Propofol is a good and safe option for conscious sedation in minor Oral and Maxillofacial Surgeries as it produces superior quality sedation without serious complications.